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Swanson Ajipure Glycine provides 500mg of Ajipure® pharmaceutical-grade glycine per capsule — the highest purity, fermentation-derived glycine from Ajinomoto Japan. Glycine is the simplest and most abundant amino acid in the human body, playing critical roles in: sleep quality improvement, gut lining integrity, collagen synthesis, liver detoxification (glycine conjugation), neurotransmission (inhibitory glycine receptors in the nervous system), and methylation cycle support. 60 vege capsules.
Glycine acts on the central nervous system through multiple mechanisms that support sleep: it activates inhibitory glycine receptors in the spinal cord and brainstem, reducing core body temperature (a key signal for sleep onset), and modulates NMDA glutamate receptors in the brain. Clinical trials show 3g of glycine taken before bed significantly improves sleep quality scores, reduces daytime fatigue, and improves subjective sleep satisfaction — without causing next-morning grogginess.
Ajipure® is Ajinomoto's (Japan) premium pharmaceutical-grade amino acid standard — produced by fermentation from plant sources (sugarcane or corn starch) under stringent pharmaceutical manufacturing conditions. Ajipure® glycine is tested to the highest purity standards, free from contaminants, and verified consistent batch-to-batch. It is the pharmaceutical and food-grade standard used by the highest-quality supplement manufacturers globally.
Glycine is essential for gut lining integrity — it is a key component of the tight junction proteins that hold intestinal epithelial cells together and prevent intestinal permeability (leaky gut). It also supports the production of bile acids (which aid fat digestion), reduces intestinal inflammation, and provides a key building block for glutathione synthesis in gut cells.
Glycine comprises approximately 33% of all amino acids in collagen — it is the most abundant amino acid in the collagen molecule. Without adequate glycine, collagen synthesis is limited. Glycine supplementation provides the substrate for collagen production in skin, tendons, cartilage, bones, and connective tissue — making it a foundational supplement for skin ageing, joint health, and connective tissue repair.
For sleep improvement: take 1–2 capsules (500–1000mg) 30–60 minutes before bed. Clinical sleep studies typically use 3g — consider 3–6 capsules for therapeutic sleep dosing. For gut health and collagen support: 1–2 capsules with meals throughout the day. Glycine is very safe at any time of day — it is gentle, non-stimulating, and well tolerated.
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