Seeking Health Riboflavin provides 100mg of vitamin B2 as riboflavin 5-phosphate (R5P) — the active coenzyme form usable directly by the body. B2 is essential for energy metabolism, MTHFR enzyme activity, glutathione recycling and antioxidant defence. Particularly important for those with MTHFR C677T variants.

Frequently Asked Questions

Why is riboflavin important for MTHFR and methylation?

The MTHFR enzyme requires riboflavin (B2) as an essential cofactor. Those with MTHFR C677T variants have reduced MTHFR enzyme activity, and supporting it with riboflavin 5-phosphate has been shown in clinical studies to significantly reduce homocysteine levels.

What is riboflavin 5-phosphate and why is it preferred?

Riboflavin 5-phosphate (R5P) is the active coenzyme form of B2 requiring no conversion — unlike plain riboflavin which must be phosphorylated. R5P provides immediate availability for FAD and FMN dependent enzymes.

What other roles does riboflavin play?

Beyond MTHFR support, B2 is essential for cellular energy production, fatty acid metabolism, glutathione recycling via glutathione reductase, and iron absorption.

What dose of riboflavin is typically used for MTHFR support?

Clinical studies investigating riboflavin and MTHFR have used doses of 1.6-10mg daily. Work with a practitioner to determine the right dose based on genetic testing and symptoms.