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Nodia contains loperamide hydrochloride 2mg — the most effective over-the-counter antidiarrhoeal medicine available. Loperamide acts directly on opioid receptors in the gut wall to slow intestinal motility, reduce fluid secretion into the bowel, and increase sphincter tone — providing fast, reliable relief from acute diarrhoea. Suitable for adults and children 12 years and over. Pharmacy Medicine (P Medicine). 16 caplets per pack.
Loperamide binds to opioid receptors (mu-receptors) in the gut wall — specifically the circular and longitudinal muscles of the intestine. This binding slows the rhythmic muscular contractions (peristalsis) that move contents through the bowel, allowing more time for water and electrolytes to be reabsorbed from the intestinal contents. It also reduces intestinal fluid secretion and increases the tone of the anal sphincter, reducing urgency and frequency of bowel movements.
Loperamide typically begins working within 1–3 hours of the first dose. Most people notice a significant reduction in frequency and urgency of loose stools within this time. For traveller's diarrhoea or acute infectious diarrhoea, symptoms often resolve within 24–48 hours of treatment.
Adults and children 12+: Take 2 caplets (4mg) initially after the first loose stool, then 1 caplet (2mg) after each subsequent loose stool. Do not exceed 8mg (4 caplets) in 24 hours for self-medication. Do not use for more than 2 days without seeking medical advice if symptoms persist.
Yes. Loperamide is widely used for IBS with predominant diarrhoea (IBS-D) to reduce stool frequency and urgency during flare-ups. It is most useful as a situational treatment — before an event, travel, or anxiety-provoking situation — rather than as a daily preventive medication. Consult your GP about long-term IBS management strategies.
Do not use loperamide if: diarrhoea is accompanied by high fever (above 38.5°C), blood in the stool, severe abdominal pain, or signs of significant dehydration (extreme thirst, no urination, confusion). These symptoms may indicate a bacterial infection (Salmonella, Campylobacter, Shigella) where loperamide could prolong the illness by slowing clearance of the pathogen. Seek medical attention rather than self-treating these presentations.
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