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NOW L-Citrulline Pure Powder provides pure pharmaceutical-grade L-citrulline in a versatile unflavoured powder — one of the most studied amino acids for supporting nitric oxide (NO) production, healthy blood flow, cardiovascular function, and athletic performance. L-citrulline is converted to L-arginine in the kidneys, which then produces nitric oxide — a potent vasodilator that relaxes blood vessels, improves circulation, and supports muscle oxygen and nutrient delivery during exercise. GMP certified, non-GMO, vegan.
L-arginine is the direct precursor to nitric oxide, but oral L-arginine supplementation is extensively broken down in the gut and liver before reaching the bloodstream — limiting how much actually reaches tissues. L-citrulline bypasses this first-pass metabolism and is converted to L-arginine in the kidneys, delivering significantly more arginine to the bloodstream where it can produce nitric oxide. Multiple studies confirm L-citrulline is more effective than L-arginine at raising plasma arginine and nitric oxide levels.
Clinical studies show L-citrulline supplementation (6–8g daily or as a pre-workout dose) improves: aerobic endurance (time to fatigue), anaerobic power output (number of reps at high intensity), delayed onset muscle soreness (DOMS) reduction, and recovery between exercise bouts. These benefits are most pronounced in endurance sports, HIIT, and strength training involving high repetition volume.
Yes. L-citrulline's nitric oxide production supports vasodilation — the relaxation of blood vessel walls — which can meaningfully reduce blood pressure in people with mild to moderate hypertension. If you take blood pressure medication, consult your GP before supplementing with L-citrulline as it may potentiate the antihypertensive effect.
For athletic performance: take 6–8g (approximately 1 heaped teaspoon) mixed in water or a pre-workout drink, 30–60 minutes before exercise. For general cardiovascular support: 3–5g daily with water. The powder is unflavoured and mixes easily into any beverage.
Yes. L-citrulline is a naturally occurring amino acid (found in watermelon) and is well tolerated at standard supplemental doses. No significant adverse effects have been reported in clinical trials. It does not share the gastrointestinal side effects sometimes seen with high-dose L-arginine supplementation.
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