Doctor's Best MSM with OptiMSM® provides methylsulfonylmethane — an organic sulphur compound and one of the most widely used joint support supplements in the world. MSM is the body's primary dietary source of bioavailable sulphur, which is essential for the synthesis of collagen, keratin, and glutathione. Doctor's Best uses OptiMSM® — the only MSM produced in the USA under cGMP standards and validated for purity by a 4-stage distillation process. Available in 1500mg tablets and 250g powder.*

• OptiMSM® — USA-made, 4-stage distilled, highest purity MSM*
• Bioavailable organic sulphur for collagen and keratin synthesis*
• Supports joint comfort, flexibility, and connective tissue integrity*
• Supports glutathione production for antioxidant defence*
• Supports hair, skin, and nail health*
• Available in 1500mg 120 tablets and 250g powder | Non-GMO | Gluten Free

Suggested Use: Tablets: 1–2 tablets daily. Powder: Mix 1 scoop (approx. 2.5g) in water or juice daily.

Frequently Asked Questions

What is MSM and why is sulphur important for joints?

MSM (methylsulfonylmethane) is a naturally occurring organic sulphur compound found in plants, animals, and humans. Sulphur is the third most abundant mineral in the body and is a critical structural component of collagen (joint cartilage matrix), keratin (hair/nails), and glutathione (the body's primary intracellular antioxidant). Supplementing with MSM helps ensure the body has adequate sulphur for maintaining these structural and protective proteins.*

What is OptiMSM and why is it superior to other MSM?

OptiMSM® is the only MSM produced in the USA under pharmaceutical cGMP standards, using a proprietary 4-stage distillation purification process. This results in a final product of exceptional purity — free from contaminants and production byproducts. Most MSM on the market is produced in China using crystallisation methods that may leave more impurities in the final product. Doctor's Best uses OptiMSM® exclusively for its quality guarantee.*

How long does it take for MSM to work for joints?

Most people notice improvements in joint comfort and mobility within 3–4 weeks of consistent daily use, with more pronounced effects developing over 12+ weeks. Clinical trials on MSM typically use 3–6g daily doses over 12 weeks. The 1500mg tablet provides a maintenance dose; those seeking more intensive support may prefer the powder to achieve higher daily doses.*

Can MSM benefit hair and skin as well as joints?

Yes. Because MSM provides bioavailable sulphur — essential for keratin (hair/nails) and collagen (skin) synthesis — many users report improvements in hair thickness, nail strength, and skin texture alongside joint benefits. MSM also supports glutathione production, which has skin-brightening antioxidant properties. These additional beauty benefits are a welcome bonus of regular MSM supplementation.*