Doctor's Best Benfotiamine 300mg is a high-potency, fat-soluble form of vitamin B1 (thiamin) that reaches significantly higher tissue concentrations than standard water-soluble thiamin. Benfotiamine activates the enzyme transketolase, which redirects harmful sugar-derived metabolites away from pathways that can damage nerves, blood vessels, and the eyes. Doctor's Best uses pharmaceutical-grade benfotiamine to ensure consistent potency and purity.*

• 300mg pharmaceutical-grade benfotiamine per capsule
• Fat-soluble B1 — significantly better absorbed than thiamin*
• Activates transketolase to block sugar-related tissue damage pathways*
• Supports healthy nerve function and peripheral circulation*
• Supports cardiovascular health and healthy ageing*
• Non-GMO | Gluten Free | Vegan | 60 veggie capsules

Suggested Use: As a dietary supplement, take 1 capsule daily with a meal, or as directed by your healthcare professional.

Frequently Asked Questions

What is benfotiamine and why is it better than regular thiamin?

Benfotiamine is an S-acyl derivative of thiamin (B1) that is fat-soluble rather than water-soluble. Studies show it achieves blood and tissue levels approximately 3–5 times higher than the same dose of regular thiamin, making it far more effective at raising intracellular B1 levels. This is critical for activating the transketolase enzyme pathway that protects cells from oxidative sugar damage.*

How does benfotiamine protect nerves?

Elevated glucose levels generate toxic metabolites through several biochemical pathways, including the hexosamine, diacylglycerol/PKC, advanced glycation end-product (AGE), and polyol pathways. Benfotiamine activates transketolase to shunt these toxic metabolites into the pentose phosphate pathway, effectively blocking all four of these damaging pathways simultaneously and protecting nerves and blood vessels from glycation-related damage.*

What is the difference between Benfotiamine 300mg and the Benfotiamine + ALA formula?

The 300mg product provides a higher dose of benfotiamine alone, making it suitable for those who want maximum benfotiamine support and may already take ALA separately. The Benfotiamine 150mg + ALA 300mg combination is ideal for those wanting both nutrients in a single, convenient capsule at moderate doses of each.*

Is benfotiamine safe for long-term daily use?

Benfotiamine has an excellent safety profile in clinical research with no significant adverse effects reported at standard doses (up to 600mg/day). As a fat-soluble vitamin B1 derivative, it does not accumulate to toxic levels. It is generally considered safe for long-term daily supplementation in healthy adults.