Doctor's Best 5-HTP 100mg is derived from the seeds of Griffonia simplicifolia — a West African plant that is the primary commercial source of 5-hydroxytryptophan (5-HTP). 5-HTP is the direct precursor to serotonin, the neurotransmitter that plays a key role in regulating mood, sleep, appetite, and stress responses. Unlike tryptophan, 5-HTP crosses the blood-brain barrier efficiently and is converted into serotonin without requiring a co-factor, making it a highly targeted approach to serotonin support.*

• Supports healthy mood and emotional wellbeing*
• Promotes restful sleep and healthy sleep cycles*
• Supports healthy appetite and weight management*
• Vegetarian and vegan-friendly | Non-GMO | Gluten Free
• 60 veggie capsules — ideal starter or travel size

Suggested Use: As a dietary supplement, take 1 capsule daily, or as recommended by a nutritionally-informed physician. For best results, take on an empty stomach 30–60 minutes before bedtime.

Frequently Asked Questions

What is 5-HTP and how does it support mood?

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid that the body uses as a direct precursor to serotonin — the "feel good" neurotransmitter. Unlike tryptophan, which must compete with other amino acids to cross the blood-brain barrier, 5-HTP crosses freely and is converted to serotonin with high efficiency. Supporting serotonin levels through 5-HTP may help maintain a positive mood, emotional balance, and a healthy stress response.*

What is the difference between the 60-cap and 180-cap 5-HTP products?

Both contain the same 100mg of 5-HTP per capsule from the same Griffonia simplicifolia source. The 60-cap size is ideal if you are trying 5-HTP for the first time or prefer a smaller supply. The 180-cap size offers better value per capsule for those already using 5-HTP regularly and wanting to maintain a longer-term supply.*

Can I take 5-HTP with antidepressants or SSRIs?

No. You should not take 5-HTP if you are currently taking SSRIs, MAOIs, SNRIs, or other medications that affect serotonin levels, as combining them may cause serotonin syndrome — a potentially serious condition. Always consult your healthcare professional before starting 5-HTP if you take any prescription medications.

When is the best time to take Doctor's Best 5-HTP?

5-HTP is most commonly taken 30–60 minutes before bedtime, as serotonin is a precursor to melatonin and may support relaxation and sleep onset. Some people also take it during the day to support daytime mood, though it is best started at a low dose and taken with food to minimise potential digestive discomfort.*