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NOW Beta Glucans Extra Strength provides 250mg of highly purified, yeast-derived beta-1,3/1,6-D-glucan per capsule — the most clinically active form of beta-glucan for immune modulation. Beta-glucans from yeast cell walls are recognised by specific receptors (Dectin-1) on immune cells (macrophages, neutrophils, NK cells) that prime and activate immune responses. Also contains larch arabinogalactan for complementary prebiotic and immune support. GMP certified, non-GMO, vegan. 60 capsules.
Beta-glucans are polysaccharides (complex sugars) found in the cell walls of yeast, oats, mushrooms, and certain bacteria. Yeast-derived beta-1,3/1,6-D-glucan is the most potent immune-active form — it binds to pattern recognition receptors (Dectin-1, CR3) on macrophages, neutrophils, and NK cells, activating these innate immune cells to increase their surveillance, killing capacity, and cytokine signalling. This priming effect helps the immune system respond faster and more effectively to pathogens without causing generalised inflammation.
Beta-glucans from different sources have different molecular structures and potencies. Yeast beta-1,3/1,6-D-glucan has the most extensive clinical evidence for immune activation and is the form used in most immune research. Oat beta-glucan (beta-1,3/1,4-D-glucan) has good evidence for cardiovascular and glycaemic health but less for immune activation. Mushroom beta-glucans (various forms) are also active but less standardised. NOW uses purified yeast-derived beta-glucan for consistent, clinically validated immune support.
Larch arabinogalactan is a highly branched polysaccharide from larch tree bark with both prebiotic and direct immune-stimulating properties. As a prebiotic, it feeds beneficial gut bacteria (Lactobacillus, Bifidobacterium) and increases short-chain fatty acid production. It also directly stimulates NK cell activity and macrophage cytokine production, complementing the beta-glucan's immune-activating effects.
Take 1 capsule daily on an empty stomach for best absorption. Beta-glucans are better absorbed away from meals — take 30 minutes before breakfast or between meals. For active immune challenge (illness onset, travel), some people take 2 capsules daily short-term.
Beta-glucans have been studied as adjunctive immune support during cancer treatment — particularly alongside chemotherapy — in multiple clinical trials. They are generally well tolerated. However, always inform your oncologist about any supplements being taken during cancer treatment, as there are specific chemotherapy protocols where immunomodulators may not be appropriate.
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