Doctor's Best Betaine HCL Pepsin & Gentian Bitters 120 capsules supports healthy digestion by helping to optimise stomach acid levels, which naturally decline with age. Adequate stomach acid (hydrochloric acid) is essential for protein digestion, mineral absorption, and preventing the overgrowth of unwanted bacteria in the upper gastrointestinal tract. This formula combines Betaine HCL to support gastric pH with Pepsin for protein digestion and Gentian Bitters to stimulate digestive secretions.*

• Betaine HCL — supports healthy stomach acid levels*
• Pepsin — proteolytic enzyme for efficient protein digestion*
• Gentian Bitters — traditional digestive bitter to stimulate secretions*
• Supports mineral and B12 absorption*
• Helps relieve symptoms of low stomach acid (hypochlorhydria)*
• 120 capsules | Non-GMO | Gluten Free

Suggested Use: Take 1 capsule with each meal containing protein, or as directed by your healthcare professional. Do not take if you have a peptic ulcer or are taking NSAIDs.

Frequently Asked Questions

What is Betaine HCL and who needs it?

Betaine hydrochloride (HCL) is a compound that provides hydrochloric acid to the stomach, supplementing natural acid production. Many people — particularly older adults — experience a decline in stomach acid secretion (hypochlorhydria), which can lead to poor protein digestion, mineral deficiencies, bloating, and reflux-like symptoms. Betaine HCL supplementation with meals can help restore optimal gastric acidity for better digestion and nutrient absorption.*

Why is pepsin included in this formula?

Pepsin is the primary protein-digesting enzyme in the stomach, and its activity is dependent on an acidic pH environment. When stomach acid is low, pepsin activity drops significantly, reducing protein digestion efficiency. By combining Betaine HCL with Pepsin, this formula restores both the acidic environment and the enzymatic capacity needed for thorough protein breakdown.*

What are Gentian Bitters and what do they do?

Gentian root is one of the most bitter plants known and has been used in traditional herbal medicine for centuries as a digestive tonic. Bitter compounds in gentian stimulate the release of saliva, bile, and digestive enzymes via a cephalic phase response — essentially priming the digestive system before and during eating. This helps improve the overall efficiency of digestion from the first bite.*

Can I take Betaine HCL if I have acid reflux or GERD?

Betaine HCL is appropriate for those with low stomach acid, but should NOT be taken by people with peptic ulcers, gastritis, or those taking NSAIDs or aspirin, as it may worsen these conditions. Counterintuitively, some acid reflux is caused by low acid (not high acid) — but you should always consult your healthcare professional before using Betaine HCL to confirm the cause of your symptoms.