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Benfotiamine is a synthetic derivative of thiamin (vitamin B1). Benfotiamine is fat-soluble, more bioavailable, and physiologically more active than thiamin. Benfotiamine helps maintain healthy cells in the presence of blood glucose, supports against oxidative stress, and supports healthy aging. Alpha-lipoic acid is a sulfur-containing fatty acid, it is soluble in both water and fat and is sometimes referred to as the “universal antioxidant”.
Benfotiamine raises the blood level of thiamin pyrophosphate, the coenzyme of thiamin, and stimulates transketolase, an enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine was shown to cause a greater thiamin concentration in red blood cells. Benfotiamine readily passes through intestinal cells and is converted into thiamin. Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells.
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